Mechanism of action

Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death

Pharmacokinetic

Meropenem is widly distributed into body tissues including bile, bronchial secreations, Kidneys, and the cerebrospinal fluid following an IV infusion (over 15-30 min.) or IV bolus inj. (over 5 min)

Absorption

Cmax - 23 ug/ml for 500 mg. dose
- 49 ug/ml for 1 gm. Dose
T max - 1 hour

Distribution

- Plasma protein binding is approx 2%
- Penetrate well in all body tissues including CSF

Excretion

• Over 70% is recovered in urine in 12 hour's
• No accumulation is observed with 500 mg. at every 8 hourly or 1 gm. at every 6 hourly
• Elimination half life :- Approx 1 hr. Laurunam
  Broad spectrum carbapenem antibiotic
• Cover most isolates