The combined confidence of infection control
An empiric choice in tough to treat intra-abdominal infections
 |
High kill power against causative pathogens
| Pathogens (Gram Negatives) |
% susceptibility |
| Enterobacter aerogenes |
74 |
| Escherichia coli |
97 |
| Klebsiella pneumoniae |
89 |
| Proteus mirabilis |
97 |
| Pseudomonas aeruginosa |
91 |
| Pathogens (Anaerobes) |
% susceptibility |
| Bacteroides fragilis |
99 |
| Other Bacteroides species |
99 |
| Pathogens (As well as Gram positives) |
% susceptibility |
| Staphylococcus aureus |
96 |
| Enterococcus faecalis |
92 |
| Streptococcus pneumoniae |
100 |
|
Better results than penems
| |
Piperacillin /
tazobactam |
Imipenem /
Cilastatin |
| Clinical response |
87% |
73% |
| Bacteriological response |
100% |
89% |
Better clinical response than Ertapenem4
| |
P/T |
Ertapenem* |
Clinical response
|
90.3% |
88.6% |
| *Ertapenem - Long acting Penem |
|
|
Recommended by the Infectious
Disease Society of America-Guidelines 2003
as initial empiric choice in acute intra-abdominal infections
Remarkably reduces the resistance in hospital setup
Decreases the resistance of Klesiella
pneumoniae and P. mirabilis in hospital setups |
Reduces the resistance to broad spectrum
cephalosporins like Ceftazidime |
Excellent cure rates in severe sepsis like
Infective episodes after
liver transplant |
88.3% |
| Intra-abdominal sepsis |
88% |
| Severe generalized peritonitis |
90% |
| Perforation of large Intestine |
73% |
| Appendicitis comlicated by repture or abscess |
90.3% |
|
Dosage and administration |
| over 30 minutes. The usual total daily dose of Lanicera for adults is 3.375 g every six hours or 4.5 g every eight hours totaling 13.5 g. (Plus an amino glycoside) totaling
18.0 g in patients with nosocomial pneumonia or patients form whom Pseudomonas aeruginosa is located. |
Recommended Dosing of Lanicera in Patients with
Normal Renal Function and Renal Insufficiency
(As total grams piperacellin/tazobactam) |
Renal Function
(Creatinine Clearance,
mL/min) |
All Indications
(except nosocomial
pneumonia) |
Nosocomial pneumonia
/ Pseudomonas
infections |
| >40 mL/.min |
3.375 q 6h |
4.5 q 6h |
| 20-40 mL/min |
2.25 q 6 h |
3.75 q 6hh |
| < 20 mL/min |
2.25 q8h |
2.25 q 6h |
Intravenous Administration
4.5 Lanicera Should be reconsituted with 20 ml diluent.
Swirl until dissolved.
Compatible with all Intravenous Diluent Solutions and
Reconstitution Diluents except Lactated Ringer's solution. |
